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pentobarbital decreases levels of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Solid CYP3A4 inducers can cut down panobinostat amounts by ~70% and bring about cure failure.pentobarbital will lessen the extent or impact of bazedoxifene/conjugated estrogens by affecting hepatic/intestinal enzyme CYP3A4 metab